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    <name language="en-US">HPO</name>
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        <designation lang="en-US" use="pref" statusCode="active" effectiveDate="" expirationDate="" count="2" length="16">Organic aciduria</designation>
        <definition lang="en-US" statusCode="active">Excretion of non-amino organic acids in urine.Excretion of non-amino organic acids in urine.</definition>
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        <designation lang="en-US" use="pref" count="4" length="34">Elevated urinary homovanillic acid</designation>
        <definition lang="en-US" >An increased concentration of homovanillic acid in the urine.An increased concentration of homovanillic acid in the urine.</definition>
        <comment lang="en-US">Homovanillic acid is the main metabolite produced from dopamine degradation by the action of monoamine oxidase. Increased levels of catecholamines or catecholamine metabolites, including dopamine, homovanillic acid (HVA) and/or vanillylmandelic acid (VMA), can be detected in the urine of 90% of all patients with neuroblastoma.Homovanillic acid is the main
            metabolite produced from dopamine degradation by the action of monoamine oxidase. Increased levels of catecholamines or catecholamine metabolites, including dopamine, homovanillic acid (HVA) and/or vanillylmandelic acid (VMA), can be detected in the urine of 90% of all patients with neuroblastoma.</comment>
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    <concept code="0040156" statusCode="active" level="2">
        <designation lang="en-US" use="pref" count="4" length="32">Elevated urinary carboxylic acid</designation>
        <definition lang="en-US">An increased amount of carboxylic acid in the urine.An increased amount of carboxylic acid in the urine.</definition>
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